FARE Clinical Trial Finder

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Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma

Study Purpose

This randomized phase III trial studies combination chemotherapy to see how well it works compared to combination chemotherapy with topotecan hydrochloride in treating patients with extracranial Ewing sarcoma that has not spread from the primary site to other places in the body. Drugs used in chemotherapy, such as vincristine sulfate, doxorubicin hydrochloride, cyclophosphamide, ifosfamide, etoposide, and topotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether combination chemotherapy is more effective with topotecan hydrochloride in treating Ewing sarcoma.

Recruitment Criteria

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Accepts Healthy Volunteers
No

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Study Type
Interventional
Eligible Ages N/A - 50 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Patients with newly diagnosed, biopsy confirmed, extracranial, non-metastatic Ewing sarcoma or primitive neuroectodermal tumor (PNET) of bone or soft tissue are eligible for this study; note: - For the purpose of this study, chest wall tumors with ipsilateral pleural effusions, ipsilateral positive pleural fluid cytology or ipsilateral pleural based secondary tumor nodules will be considered localized disease - Patients with regional node involvement, based on clinical suspicion confirmed by pathologic documentation are considered to be non-metastatic - Patients with discontinuous osseous lesions within the same bone are considered to be non-metastatic - Tumors arising in the bony skull (extra-dural) are considered to be extracranial - Patient eligibility will be based on a diagnosis of Ewing sarcoma or PNET by institutional pathologist - No prior chemotherapy or radiation therapy is allowed; patients should only have had a biopsy of the primary tumor without an attempt at complete or partial resection; patients will still be eligible if unplanned excision was attempted or accomplished as long as adequate imaging was obtained prior to surgery - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2 or serum creatinine based on age/gender as follows: - 1 month to < 6 months: 0.4 mg/dL - 6 months to < 1 year: 0.5 mg/dL - 1 to < 2 years: 0.6 mg/dL - 2 to < 6 years: 0.8 mg/dL - 6 to < 10 years: 1 mg/dL - 10 to < 13 years: 1.2 mg/dL - 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female) - >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female) - Total bilirubin < 1.5 x upper limit of normal (ULN) for age - Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x upper limit of normal (ULN) for age - Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram

Exclusion Criteria:

- Patients must have no evidence of metastatic disease; metastatic disease: - Are lesions which are discontinuous from the primary tumor, are not regional lymph nodes and do not share a body cavity with the primary tumor; if there is any doubt whether lesions are metastatic, a biopsy of those lesions should be taken - Skeletal lesions in adjacent bones (trans-articular) - Contralateral pleural effusion and contralateral pleural nodules - Distant lymph node involvement - Patients with pulmonary nodules are considered to have metastatic disease if the patient has: - Solitary nodule > 0.5 cm or multiple nodules of > 0.3 cm unless biopsied and negative for Ewing's - Biopsies of solitary nodule =< 0.5 cm or multiple nodules =< 0.3 cm are not required but if performed and positive indicate metastatic disease - Patients whose tumors arise in the dural and intra-dural soft tissues of the cranium and spine are not eligible - Patients with pathologic diagnoses other than Ewing sarcoma will be excluded - Patients diagnosed with Ewing Sarcoma as a second malignant neoplasm are not eligible if they have received chemotherapy or radiation for the treatment of their primary malignancy - Pregnant women will not be entered on this study; pregnancy tests must be obtained in female patients who are post-menarchal; lactating females may not participate unless they have agreed not to breastfeed their infants; males or females of reproductive potential may not participate unless they have agreed to use an effective contraceptive method for the duration of the study treatment - All patients and/or their parents or legal guardians must sign a written informed consent - All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Trial Details

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

Trial ID:
NCT01231906

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase
Phase 3

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Lead Sponsor
Children's Oncology Group

The person who is responsible for the scientific and technical direction of the entire clinical study.

Principal Investigator
Patrick J Leavey
Principal Investigator Affiliation Children's Oncology Group

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Agency Class
OtherNIH
Overall Status Active, not recruiting
Countries Australia, Canada, New Zealand, Puerto Rico, Saudi Arabia, United States

The disease, disorder, syndrome, illness, or injury that is being studied.

Conditions
Non-Metastatic Extraskeletal Ewing Sarcoma, Peripheral Primitive Neuroectodermal Tumor of Bone, Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
Additional Details

PRIMARY OBJECTIVES: l. Test the effect of the combination of vincristine (vincristine sulfate), cyclophosphamide, and topotecan (topotecan hydrochloride) (VTC) added to the standard 5-drug chemotherapy interval-compressed backbone on event-free and overall survival of children and young adults with Ewing sarcoma. SECONDARY OBJECTIVES:

  • I. To evaluate initial volumetric tumor size as a prognostic factor for event free survival (EFS) in patients with localized Ewing tumors.
  • II. To evaluate histologic response as a prognostic factor for EFS in patients with localized Ewing tumors.
  • III. To continue evaluation of biologic markers both as related to prognosis and as eventual therapeutic targets via encouraging concurrent enrollment on a Ewing sarcoma specimen-collection study.
  • IV. To evaluate imaging response by fludeoxyglucose F 18 (FDG)-positron emission tomography (PET) as a prognostic factor for EFS.
  • V. To evaluate the effects of the type of local therapy on EFS and overall survival.
  • VI. To evaluate the effect of local surgical margins in conjunction with histologic response on EFS in patients with localized Ewing tumors.
  • VII. To evaluate the effect of local therapy modality (surgery, radiotherapy, or a combination) as well as the type of surgical reconstruction on musculoskeletal complications.
OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM I: INDUCTION THERAPY: Patients receive vincristine sulfate intravenously (IV) on day 1 in weeks 1, 2, 5, 6, 9, and 10; doxorubicin hydrochloride IV on days 1 and 2 and cyclophosphamide IV over 30-60 minutes on day 1 in weeks 1, 5, and 9; and ifosfamide IV over 1 hour and etoposide IV over 1-2 hours on days 1-5 in weeks 3, 7, and 11. CONSOLIDATION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 7, 8, 9, 10, 13, 14, 17, 18, 21, and 22; doxorubicin hydrochloride IV on days 1 and 2 in weeks 1 and 9; cyclophosphamide IV over 30-60 minutes on day 1 in weeks 1, 7, 9, 13, 17, and 21; and ifosfamide IV over 1 hour and etoposide IV over 1-2 hours on days 1-5 in weeks 3, 5, 11, 15, and 19. ARM II: INDUCTION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 5, 6, 9, 10, 11 and 12; topotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1 and 9; cyclophosphamide IV over 15-60 minutes on days 1-5 in weeks 1 and 9, and on day 1 of weeks 5 and 11; ifosfamide and etoposide as in arm I; and doxorubicin hydrochloride IV on days 1 and 2 in weeks 5 and 11. CONSOLIDATION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 7-10, 13-16, 19, and 20; topotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1, 7, and 15; cyclophosphamide IV over 15-60 minutes on days 1-5 in weeks 1, 7, and 15, and on day 1 in weeks 9, 13, and 19; ifosfamide IV over 1 hour and etoposide IV over 1- 2 hours on days 1-5 in weeks 3, 5, 11, 17, and 21; and doxorubicin hydrochloride IV on days 1 and 2 in weeks 9,13, and 19. Patients with responsive or stable disease undergo may undergo surgery alone in week 13 if lesion can be complete resected with negative margins and with reasonable functional result. Patients with unresectable lesions or inadequate margins after surgery receive radiotherapy during weeks 1-7. Patients with bulky lesions in surgically difficult sites such as the spine, skull, and periacetabular pelvis, patients with a poor response to induction chemotherapy, or those patients in whom surgery would result in unacceptable functional results may undergo radiotherapy alone in weeks 1-7 of consolidation therapy, and surgery should be performed after completion of consolidation chemotherapy. Patients with microscopic residual disease after planned pre-operative radiotherapy receive additional radiotherapy. After completion of study therapy, patients are followed up every 3 months for 3 years and then every 6 months for 2 years.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Milwaukee, Wisconsin

Status

Address

Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Status

Address

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53226

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Status

Address

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

Madison, Wisconsin

Status

Address

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792

Green Bay, Wisconsin

Status

Address

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301

Camden Clark Medical Center, Parkersburg, West Virginia

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Address

Camden Clark Medical Center

Parkersburg, West Virginia, 26101

West Virginia University Healthcare, Morgantown, West Virginia

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Address

West Virginia University Healthcare

Morgantown, West Virginia, 26506

Charleston, West Virginia

Status

Address

West Virginia University Charleston Division

Charleston, West Virginia, 25304

United Hospital Center, Bridgeport, West Virginia

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United Hospital Center

Bridgeport, West Virginia, 26330

Madigan Army Medical Center, Tacoma, Washington

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Madigan Army Medical Center

Tacoma, Washington, 98431

Tacoma, Washington

Status

Address

Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, 98405

Spokane, Washington

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Address

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, Washington, 99204

University of Washington Medical Center, Seattle, Washington

Status

Address

University of Washington Medical Center

Seattle, Washington, 98195

Seattle Children's Hospital, Seattle, Washington

Status

Address

Seattle Children's Hospital

Seattle, Washington, 98105

Carilion Clinic Children's Hospital, Roanoke, Virginia

Status

Address

Carilion Clinic Children's Hospital

Roanoke, Virginia, 24014

Richmond, Virginia

Status

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Naval Medical Center - Portsmouth, Portsmouth, Virginia

Status

Address

Naval Medical Center - Portsmouth

Portsmouth, Virginia, 23708-2197

Norfolk, Virginia

Status

Address

Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507

Inova Fairfax Hospital, Falls Church, Virginia

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Address

Inova Fairfax Hospital

Falls Church, Virginia, 22042

University of Virginia Cancer Center, Charlottesville, Virginia

Status

Address

University of Virginia Cancer Center

Charlottesville, Virginia, 22908

Burlington, Vermont

Status

Address

University of Vermont College of Medicine

Burlington, Vermont, 05405

Primary Children's Hospital, Salt Lake City, Utah

Status

Address

Primary Children's Hospital

Salt Lake City, Utah, 84113

Scott and White Memorial Hospital, Temple, Texas

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Address

Scott and White Memorial Hospital

Temple, Texas, 76508

San Antonio, Texas

Status

Address

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229

San Antonio, Texas

Status

Address

Methodist Children's Hospital of South Texas

San Antonio, Texas, 78229

Children's Hospital of San Antonio, San Antonio, Texas

Status

Address

Children's Hospital of San Antonio

San Antonio, Texas, 78207

Covenant Children's Hospital, Lubbock, Texas

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Address

Covenant Children's Hospital

Lubbock, Texas, 79410

M D Anderson Cancer Center, Houston, Texas

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Address

M D Anderson Cancer Center

Houston, Texas, 77030

Houston, Texas

Status

Address

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030

Cook Children's Medical Center, Fort Worth, Texas

Status

Address

Cook Children's Medical Center

Fort Worth, Texas, 76104

Brooke Army Medical Center, Fort Sam Houston, Texas

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Address

Brooke Army Medical Center

Fort Sam Houston, Texas, 78234

El Paso Children's Hospital, El Paso, Texas

Status

Address

El Paso Children's Hospital

El Paso, Texas, 79905

Dallas, Texas

Status

Address

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

Medical City Dallas Hospital, Dallas, Texas

Status

Address

Medical City Dallas Hospital

Dallas, Texas, 75230

Driscoll Children's Hospital, Corpus Christi, Texas

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Address

Driscoll Children's Hospital

Corpus Christi, Texas, 78411

Austin, Texas

Status

Address

Dell Children's Medical Center of Central Texas

Austin, Texas, 78723

Nashville, Tennessee

Status

Address

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

St. Jude Children's Research Hospital, Memphis, Tennessee

Status

Address

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105

East Tennessee Childrens Hospital, Knoxville, Tennessee

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Address

East Tennessee Childrens Hospital

Knoxville, Tennessee, 37916

T C Thompson Children's Hospital, Chattanooga, Tennessee

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Address

T C Thompson Children's Hospital

Chattanooga, Tennessee, 37403

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

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Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

Greenville Cancer Treatment Center, Greenville, South Carolina

Status

Address

Greenville Cancer Treatment Center

Greenville, South Carolina, 29605

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

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Address

BI-LO Charities Children's Cancer Center

Greenville, South Carolina, 29605

Palmetto Health Richland, Columbia, South Carolina

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Address

Palmetto Health Richland

Columbia, South Carolina, 29203

Medical University of South Carolina, Charleston, South Carolina

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Address

Medical University of South Carolina

Charleston, South Carolina, 29425

Rhode Island Hospital, Providence, Rhode Island

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Address

Rhode Island Hospital

Providence, Rhode Island, 02903

Pittsburgh, Pennsylvania

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Address

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224

Philadelphia, Pennsylvania

Status

Address

Saint Christopher's Hospital for Children

Philadelphia, Pennsylvania, 19134

Fox Chase Cancer Center, Philadelphia, Pennsylvania

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Address

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

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Address

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104

Penn State Children's Hospital, Hershey, Pennsylvania

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Address

Penn State Children's Hospital

Hershey, Pennsylvania, 17033

Geisinger Medical Center, Danville, Pennsylvania

Status

Address

Geisinger Medical Center

Danville, Pennsylvania, 17822

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania

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Address

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017

Oregon Health and Science University, Portland, Oregon

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Address

Oregon Health and Science University

Portland, Oregon, 97239

Portland, Oregon

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Address

Legacy Emanuel Hospital and Health Center

Portland, Oregon, 97227

Legacy Emanuel Children's Hospital, Portland, Oregon

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Address

Legacy Emanuel Children's Hospital

Portland, Oregon, 97227

Providence Saint Vincent Medical Center, Portland, Oregon

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Address

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

Tulsa, Oklahoma

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Address

Natalie Warren Bryant Cancer Center at Saint Francis

Tulsa, Oklahoma, 74136

Oklahoma City, Oklahoma

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Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Mercy Children's Hospital, Toledo, Ohio

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Mercy Children's Hospital

Toledo, Ohio, 43608

Toledo, Ohio

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Address

The Toledo Hospital/Toledo Children's Hospital

Toledo, Ohio, 43606

Dayton Children's Hospital, Dayton, Ohio

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Address

Dayton Children's Hospital

Dayton, Ohio, 45404

Nationwide Children's Hospital, Columbus, Ohio

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Nationwide Children's Hospital

Columbus, Ohio, 43205

Cleveland Clinic Foundation, Cleveland, Ohio

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Address

Cleveland Clinic Foundation

Cleveland, Ohio, 44195

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

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Address

Rainbow Babies and Childrens Hospital

Cleveland, Ohio, 44106

Cincinnati, Ohio

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Address

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229

Akron, Ohio

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Address

Children's Hospital Medical Center of Akron

Akron, Ohio, 44308

Sanford Broadway Medical Center, Fargo, North Dakota

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Address

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

Wake Forest University Health Sciences, Winston-Salem, North Carolina

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Address

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157

Duke University Medical Center, Durham, North Carolina

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Address

Duke University Medical Center

Durham, North Carolina, 27710

Charlotte, North Carolina

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Address

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204

Charlotte, North Carolina

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Address

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203

Chapel Hill, North Carolina

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Address

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599

Mission Hospital Inc-Memorial Campus, Asheville, North Carolina

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Address

Mission Hospital Inc-Memorial Campus

Asheville, North Carolina, 28801

New York Medical College, Valhalla, New York

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Address

New York Medical College

Valhalla, New York, 10595

Syracuse, New York

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Address

State University of New York Upstate Medical University

Syracuse, New York, 13210

Stony Brook University Medical Center, Stony Brook, New York

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Address

Stony Brook University Medical Center

Stony Brook, New York, 11794

University of Rochester, Rochester, New York

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University of Rochester

Rochester, New York, 14642

New York, New York

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Address

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

Mount Sinai Hospital, New York, New York

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Address

Mount Sinai Hospital

New York, New York, 10029

New York, New York

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Address

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016

New Hyde Park, New York

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Address

The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, New York, 11040

Roswell Park Cancer Institute, Buffalo, New York

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Address

Roswell Park Cancer Institute

Buffalo, New York, 14263

Montefiore Medical Center - Moses Campus, Bronx, New York

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Address

Montefiore Medical Center - Moses Campus

Bronx, New York, 10467

Albany Medical Center, Albany, New York

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Address

Albany Medical Center

Albany, New York, 12208

University of New Mexico Cancer Center, Albuquerque, New Mexico

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Address

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102

Overlook Hospital, Summit, New Jersey

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Address

Overlook Hospital

Summit, New Jersey, 07902

Saint Joseph's Regional Medical Center, Paterson, New Jersey

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Saint Joseph's Regional Medical Center

Paterson, New Jersey, 07503

Newark Beth Israel Medical Center, Newark, New Jersey

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Newark Beth Israel Medical Center

Newark, New Jersey, 07112

New Brunswick, New Jersey

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Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, New Jersey, 08903

Saint Peter's University Hospital, New Brunswick, New Jersey

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Address

Saint Peter's University Hospital

New Brunswick, New Jersey, 08901

Morristown Medical Center, Morristown, New Jersey

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Address

Morristown Medical Center

Morristown, New Jersey, 07960

Saint Barnabas Medical Center, Livingston, New Jersey

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Address

Saint Barnabas Medical Center

Livingston, New Jersey, 07039

Hackensack University Medical Center, Hackensack, New Jersey

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Address

Hackensack University Medical Center

Hackensack, New Jersey, 07601

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

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Address

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756

Saint Mary's Regional Medical Center, Reno, Nevada

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Address

Saint Mary's Regional Medical Center

Reno, Nevada, 89503

Summerlin Hospital Medical Center, Las Vegas, Nevada

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Address

Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144

Las Vegas, Nevada

Status

Address

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135

Sunrise Hospital and Medical Center, Las Vegas, Nevada

Status

Address

Sunrise Hospital and Medical Center

Las Vegas, Nevada, 89109

Nevada Cancer Research Foundation CCOP, Las Vegas, Nevada

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Address

Nevada Cancer Research Foundation CCOP

Las Vegas, Nevada, 89106

Las Vegas, Nevada

Status

Address

University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102

University of Nebraska Medical Center, Omaha, Nebraska

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Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Omaha, Nebraska

Status

Address

Children's Hospital and Medical Center of Omaha

Omaha, Nebraska, 68114

Mercy Hospital Saint Louis, Saint Louis, Missouri

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Address

Mercy Hospital Saint Louis

Saint Louis, Missouri, 63141

Washington University School of Medicine, Saint Louis, Missouri

Status

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Status

Address

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108

Columbia Regional, Columbia, Missouri

Status

Address

Columbia Regional

Columbia, Missouri, 65201

University of Mississippi Medical Center, Jackson, Mississippi

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Address

University of Mississippi Medical Center

Jackson, Mississippi, 39216

Mayo Clinic, Rochester, Minnesota

Status

Address

Mayo Clinic

Rochester, Minnesota, 55905

Minneapolis, Minnesota

Status

Address

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455

Minneapolis, Minnesota

Status

Address

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, 55404

Beaumont Children's Hospital-Royal Oak, Royal Oak, Michigan

Status

Address

Beaumont Children's Hospital-Royal Oak

Royal Oak, Michigan, 48073

Yale University, New Haven, Connecticut

Status

Address

Yale University

New Haven, Connecticut, 06520

Connecticut Children's Medical Center, Hartford, Connecticut

Status

Address

Connecticut Children's Medical Center

Hartford, Connecticut, 06106

Denver, Colorado

Status

Address

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

Denver, Colorado, 80218

Children's Hospital Colorado, Aurora, Colorado

Status

Address

Children's Hospital Colorado

Aurora, Colorado, 80045

UCSF Medical Center-Mission Bay, San Francisco, California

Status

Address

UCSF Medical Center-Mission Bay

San Francisco, California, 94158

UCSF Medical Center-Parnassus, San Francisco, California

Status

Address

UCSF Medical Center-Parnassus

San Francisco, California, 94143

Rady Children's Hospital - San Diego, San Diego, California

Status

Address

Rady Children's Hospital - San Diego

San Diego, California, 92123

Sacramento, California

Status

Address

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

Sutter Medical Center Sacramento, Sacramento, California

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Address

Sutter Medical Center Sacramento

Sacramento, California, 95816

Palo Alto, California

Status

Address

Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304

Orange, California

Status

Address

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868

Children's Hospital of Orange County, Orange, California

Status

Address

Children's Hospital of Orange County

Orange, California, 92868

Kaiser Permanente-Oakland, Oakland, California

Status

Address

Kaiser Permanente-Oakland

Oakland, California, 94611

Oakland, California

Status

Address

Children's Hospital and Research Center at Oakland

Oakland, California, 94609-1809

Valley Children's Hospital, Madera, California

Status

Address

Valley Children's Hospital

Madera, California, 93636

Los Angeles, California

Status

Address

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095

Mattel Children's Hospital UCLA, Los Angeles, California

Status

Address

Mattel Children's Hospital UCLA

Los Angeles, California, 90095

Cedars Sinai Medical Center, Los Angeles, California

Status

Address

Cedars Sinai Medical Center

Los Angeles, California, 90048

USC / Norris Comprehensive Cancer Center, Los Angeles, California

Status

Address

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033

Los Angeles County-USC Medical Center, Los Angeles, California

Status

Address

Los Angeles County-USC Medical Center

Los Angeles, California, 90033

Children's Hospital Los Angeles, Los Angeles, California

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Address

Children's Hospital Los Angeles

Los Angeles, California, 90027

Long Beach, California

Status

Address

Miller Children's and Women's Hospital Long Beach

Long Beach, California, 90806

Loma Linda University Medical Center, Loma Linda, California

Status

Address

Loma Linda University Medical Center

Loma Linda, California, 92354

City of Hope Comprehensive Cancer Center, Duarte, California

Status

Address

City of Hope Comprehensive Cancer Center

Duarte, California, 91010

Kaiser Permanente Downey Medical Center, Downey, California

Status

Address

Kaiser Permanente Downey Medical Center

Downey, California, 90242

Little Rock, Arkansas

Status

Address

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

Arkansas Children's Hospital, Little Rock, Arkansas

Status

Address

Arkansas Children's Hospital

Little Rock, Arkansas, 72202-3591

Tucson, Arizona

Status

Address

The University of Arizona Medical Center-University Campus

Tucson, Arizona, 85724

Phoenix Childrens Hospital, Phoenix, Arizona

Status

Address

Phoenix Childrens Hospital

Phoenix, Arizona, 85016

Providence Alaska Medical Center, Anchorage, Alaska

Status

Address

Providence Alaska Medical Center

Anchorage, Alaska, 99508

USA Health Strada Patient Care Center, Mobile, Alabama

Status

Address

USA Health Strada Patient Care Center

Mobile, Alabama, 36604

Birmingham, Alabama

Status

Address

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

Children's Hospital of Alabama, Birmingham, Alabama

Status

Address

Children's Hospital of Alabama

Birmingham, Alabama, 35233

Bronson Methodist Hospital, Kalamazoo, Michigan

Status

Address

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

Grand Rapids, Michigan

Status

Address

Helen DeVos Children's Hospital at Spectrum Health

Grand Rapids, Michigan, 49503

Hurley Medical Center, Flint, Michigan

Status

Address

Hurley Medical Center

Flint, Michigan, 48503

East Lansing, Michigan

Status

Address

Michigan State University Clinical Center

East Lansing, Michigan, 48824-7016

Ascension Saint John Hospital, Detroit, Michigan

Status

Address

Ascension Saint John Hospital

Detroit, Michigan, 48236

Detroit, Michigan

Status

Address

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201

C S Mott Children's Hospital, Ann Arbor, Michigan

Status

Address

C S Mott Children's Hospital

Ann Arbor, Michigan, 48109

Worcester, Massachusetts

Status

Address

University of Massachusetts Medical School

Worcester, Massachusetts, 01655

Baystate Medical Center, Springfield, Massachusetts

Status

Address

Baystate Medical Center

Springfield, Massachusetts, 01199

Dana-Farber Cancer Institute, Boston, Massachusetts

Status

Address

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215

Boston, Massachusetts

Status

Address

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114

Bethesda, Maryland

Status

Address

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600

Baltimore, Maryland

Status

Address

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

Sinai Hospital of Baltimore, Baltimore, Maryland

Status

Address

Sinai Hospital of Baltimore

Baltimore, Maryland, 21215

Baltimore, Maryland

Status

Address

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

Maine Children's Cancer Program, Scarborough, Maine

Status

Address

Maine Children's Cancer Program

Scarborough, Maine, 04074

Eastern Maine Medical Center, Bangor, Maine

Status

Address

Eastern Maine Medical Center

Bangor, Maine, 04401

Ochsner Medical Center Jefferson, New Orleans, Louisiana

Status

Address

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121

Children's Hospital New Orleans, New Orleans, Louisiana

Status

Address

Children's Hospital New Orleans

New Orleans, Louisiana, 70118

Tulane University Health Sciences Center, New Orleans, Louisiana

Status

Address

Tulane University Health Sciences Center

New Orleans, Louisiana, 70112

Norton Children's Hospital, Louisville, Kentucky

Status

Address

Norton Children's Hospital

Louisville, Kentucky, 40202

Lexington, Kentucky

Status

Address

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

Saint Luke's Regional Medical Center, Sioux City, Iowa

Status

Address

Saint Luke's Regional Medical Center

Sioux City, Iowa, 51104

Mercy Medical Center-Sioux City, Sioux City, Iowa

Status

Address

Mercy Medical Center-Sioux City

Sioux City, Iowa, 51102

Siouxland Regional Cancer Center, Sioux City, Iowa

Status

Address

Siouxland Regional Cancer Center

Sioux City, Iowa, 51101

Iowa City, Iowa

Status

Address

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242

Blank Children's Hospital, Des Moines, Iowa

Status

Address

Blank Children's Hospital

Des Moines, Iowa, 50309

Indianapolis, Indiana

Status

Address

Saint Vincent Hospital and Health Care Center

Indianapolis, Indiana, 46260

Riley Hospital for Children, Indianapolis, Indiana

Status

Address

Riley Hospital for Children

Indianapolis, Indiana, 46202

Indianapolis, Indiana

Status

Address

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202

Memorial Medical Center, Springfield, Illinois

Status

Address

Memorial Medical Center

Springfield, Illinois, 62781

Springfield, Illinois

Status

Address

Southern Illinois University School of Medicine

Springfield, Illinois, 62702

Saint John's Hospital, Springfield, Illinois

Status

Address

Saint John's Hospital

Springfield, Illinois, 62702

Saint Jude Midwest Affiliate, Peoria, Illinois

Status

Address

Saint Jude Midwest Affiliate

Peoria, Illinois, 61637

Advocate Lutheran General Hospital, Park Ridge, Illinois

Status

Address

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068

Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois

Status

Address

Advocate Children's Hospital-Park Ridge

Park Ridge, Illinois, 60068

Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois

Status

Address

Advocate Children's Hospital-Oak Lawn

Oak Lawn, Illinois, 60453

Loyola University Medical Center, Maywood, Illinois

Status

Address

Loyola University Medical Center

Maywood, Illinois, 60153

Chicago, Illinois

Status

Address

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

University of Illinois, Chicago, Illinois

Status

Address

University of Illinois

Chicago, Illinois, 60612

Northwestern University, Chicago, Illinois

Status

Address

Northwestern University

Chicago, Illinois, 60611

Lurie Children's Hospital-Chicago, Chicago, Illinois

Status

Address

Lurie Children's Hospital-Chicago

Chicago, Illinois, 60611

Boise, Idaho

Status

Address

Saint Luke's Mountain States Tumor Institute

Boise, Idaho, 83712

Tripler Army Medical Center, Honolulu, Hawaii

Status

Address

Tripler Army Medical Center

Honolulu, Hawaii, 96859

Honolulu, Hawaii

Status

Address

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826

University of Hawaii Cancer Center, Honolulu, Hawaii

Status

Address

University of Hawaii Cancer Center

Honolulu, Hawaii, 96813

Straub Clinic and Hospital, Honolulu, Hawaii

Status

Address

Straub Clinic and Hospital

Honolulu, Hawaii, 96813

Savannah, Georgia

Status

Address

Memorial Health University Medical Center

Savannah, Georgia, 31404

Augusta University Medical Center, Augusta, Georgia

Status

Address

Augusta University Medical Center

Augusta, Georgia, 30912

Atlanta, Georgia

Status

Address

Children's Healthcare of Atlanta - Egleston

Atlanta, Georgia, 30322

Saint Mary's Hospital, West Palm Beach, Florida

Status

Address

Saint Mary's Hospital

West Palm Beach, Florida, 33407

Tampa, Florida

Status

Address

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Status

Address

Johns Hopkins All Children's Hospital

Saint Petersburg, Florida, 33701

Nemours Children's Clinic - Pensacola, Pensacola, Florida

Status

Address

Nemours Children's Clinic - Pensacola

Pensacola, Florida, 32504

Nemours Children's Hospital, Orlando, Florida

Status

Address

Nemours Children's Hospital

Orlando, Florida, 32827

UF Cancer Center at Orlando Health, Orlando, Florida

Status

Address

UF Cancer Center at Orlando Health

Orlando, Florida, 32806

Nemours Children's Clinic - Orlando, Orlando, Florida

Status

Address

Nemours Children's Clinic - Orlando

Orlando, Florida, 32806

Arnold Palmer Hospital for Children, Orlando, Florida

Status

Address

Arnold Palmer Hospital for Children

Orlando, Florida, 32806

Florida Hospital Orlando, Orlando, Florida

Status

Address

Florida Hospital Orlando

Orlando, Florida, 32803

Miami Cancer Institute, Miami, Florida

Status

Address

Miami Cancer Institute

Miami, Florida, 33176

Miami, Florida

Status

Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

Status

Address

Nemours Children's Clinic-Jacksonville

Jacksonville, Florida, 32207

Hollywood, Florida

Status

Address

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, Florida, 33021

Gainesville, Florida

Status

Address

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

Fort Myers, Florida

Status

Address

Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, 33908

Lee Memorial Health System, Fort Myers, Florida

Status

Address

Lee Memorial Health System

Fort Myers, Florida, 33901

Broward Health Medical Center, Fort Lauderdale, Florida

Status

Address

Broward Health Medical Center

Fort Lauderdale, Florida, 33316

Children's National Medical Center, Washington, District of Columbia

Status

Address

Children's National Medical Center

Washington, District of Columbia, 20010

MedStar Georgetown University Hospital, Washington, District of Columbia

Status

Address

MedStar Georgetown University Hospital

Washington, District of Columbia, 20007

Alfred I duPont Hospital for Children, Wilmington, Delaware

Status

Address

Alfred I duPont Hospital for Children

Wilmington, Delaware, 19803

International Sites

Riyadh, Saudi Arabia

Status

Address

King Faisal Specialist Hospital and Research Centre

Riyadh, , 11211

San Jorge Children's Hospital, San Juan, Puerto Rico

Status

Address

San Jorge Children's Hospital

San Juan, , 00912

Christchurch Hospital, Christchurch, New Zealand

Status

Address

Christchurch Hospital

Christchurch, , 8011

Starship Children's Hospital, Grafton, Auckland, New Zealand

Status

Address

Starship Children's Hospital

Grafton, Auckland, 1145

Quebec, Canada

Status

Address

Centre Hospitalier Universitaire de Quebec

Quebec, , G1V 4G2

Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Status

Address

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Status

Address

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1

Montreal, Quebec, Canada

Status

Address

Centre Hospitalier Universitaire Sainte-Justine

Montreal, Quebec, H3T 1C5

Montreal, Quebec, Canada

Status

Address

The Montreal Children's Hospital of the MUHC

Montreal, Quebec, H3H 1P3

Hospital for Sick Children, Toronto, Ontario, Canada

Status

Address

Hospital for Sick Children

Toronto, Ontario, M5G 1X8

Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada

Status

Address

Children's Hospital of Eastern Ontario

Ottawa, Ontario, K1H 8L1

Children's Hospital, London, Ontario, Canada

Status

Address

Children's Hospital

London, Ontario, N6A 5W9

Kingston Health Sciences Centre, Kingston, Ontario, Canada

Status

Address

Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7

Hamilton, Ontario, Canada

Status

Address

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Ontario, L8N 3Z5

IWK Health Centre, Halifax, Nova Scotia, Canada

Status

Address

IWK Health Centre

Halifax, Nova Scotia, B3K 6R8

Janeway Child Health Centre, Saint John's, Newfoundland and Labrador, Canada

Status

Address

Janeway Child Health Centre

Saint John's, Newfoundland and Labrador, A1B 3V6

CancerCare Manitoba, Winnipeg, Manitoba, Canada

Status

Address

CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9

British Columbia Children's Hospital, Vancouver, British Columbia, Canada

Status

Address

British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3V4

University of Alberta Hospital, Edmonton, Alberta, Canada

Status

Address

University of Alberta Hospital

Edmonton, Alberta, T6G 2B7

Alberta Children's Hospital, Calgary, Alberta, Canada

Status

Address

Alberta Children's Hospital

Calgary, Alberta, T3B 6A8

Princess Margaret Hospital for Children, Perth, Western Australia, Australia

Status

Address

Princess Margaret Hospital for Children

Perth, Western Australia, 6008

Women's and Children's Hospital-Adelaide, North Adelaide, South Australia, Australia

Status

Address

Women's and Children's Hospital-Adelaide

North Adelaide, South Australia, 5006

Queensland Children's Hospital, South Brisbane, Queensland, Australia

Status

Address

Queensland Children's Hospital

South Brisbane, Queensland, 4101

Royal Children's Hospital-Brisbane, Herston, Queensland, Australia

Status

Address

Royal Children's Hospital-Brisbane

Herston, Queensland, 4029

Royal Brisbane and Women's Hospital, Herston, Queensland, Australia

Status

Address

Royal Brisbane and Women's Hospital

Herston, Queensland, 4029

The Children's Hospital at Westmead, Westmead, New South Wales, Australia

Status

Address

The Children's Hospital at Westmead

Westmead, New South Wales, 2145

Sydney Children's Hospital, Randwick, New South Wales, Australia

Status

Address

Sydney Children's Hospital

Randwick, New South Wales, 2031

John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales, Australia

Status

Address

John Hunter Children's Hospital

Hunter Regional Mail Centre, New South Wales, 2310

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