FARE Clinical Trial Finder

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Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma

Study Purpose

This randomized phase III trial studies combination chemotherapy to see how well it works compared to combination chemotherapy with topotecan hydrochloride in treating patients with extracranial Ewing sarcoma that has not spread from the primary site to other places in the body. Drugs used in chemotherapy, such as vincristine sulfate, doxorubicin hydrochloride, cyclophosphamide, ifosfamide, etoposide, and topotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether combination chemotherapy is more effective with topotecan hydrochloride in treating Ewing sarcoma.

Recruitment Criteria

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Accepts Healthy Volunteers
No

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Study Type
Interventional
Eligible Ages N/A - 50 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Patients with newly diagnosed, biopsy confirmed, extracranial, non-metastatic Ewing sarcoma or primitive neuroectodermal tumor (PNET) of bone or soft tissue are eligible for this study; note: - For the purpose of this study, chest wall tumors with ipsilateral pleural effusions, ipsilateral positive pleural fluid cytology or ipsilateral pleural based secondary tumor nodules will be considered localized disease - Patients with regional node involvement, based on clinical suspicion confirmed by pathologic documentation are considered to be non-metastatic - Patients with discontinuous osseous lesions within the same bone are considered to be non-metastatic - Tumors arising in the bony skull (extra-dural) are considered to be extracranial - Patient eligibility will be based on a diagnosis of Ewing sarcoma or PNET by institutional pathologist - No prior chemotherapy or radiation therapy is allowed; patients should only have had a biopsy of the primary tumor without an attempt at complete or partial resection; patients will still be eligible if unplanned excision was attempted or accomplished as long as adequate imaging was obtained prior to surgery - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2 or serum creatinine based on age/gender as follows: - 1 month to < 6 months: 0.4 mg/dL - 6 months to < 1 year: 0.5 mg/dL - 1 to < 2 years: 0.6 mg/dL - 2 to < 6 years: 0.8 mg/dL - 6 to < 10 years: 1 mg/dL - 10 to < 13 years: 1.2 mg/dL - 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female) - >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female) - Total bilirubin < 1.5 x upper limit of normal (ULN) for age - Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x upper limit of normal (ULN) for age - Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram

Exclusion Criteria:

- Patients must have no evidence of metastatic disease; metastatic disease: - Are lesions which are discontinuous from the primary tumor, are not regional lymph nodes and do not share a body cavity with the primary tumor; if there is any doubt whether lesions are metastatic, a biopsy of those lesions should be taken - Skeletal lesions in adjacent bones (trans-articular) - Contralateral pleural effusion and contralateral pleural nodules - Distant lymph node involvement - Patients with pulmonary nodules are considered to have metastatic disease if the patient has: - Solitary nodule > 0.5 cm or multiple nodules of > 0.3 cm unless biopsied and negative for Ewing's - Biopsies of solitary nodule =< 0.5 cm or multiple nodules =< 0.3 cm are not required but if performed and positive indicate metastatic disease - Patients whose tumors arise in the dural and intra-dural soft tissues of the cranium and spine are not eligible - Patients with pathologic diagnoses other than Ewing sarcoma will be excluded - Patients diagnosed with Ewing Sarcoma as a second malignant neoplasm are not eligible if they have received chemotherapy or radiation for the treatment of their primary malignancy - Pregnant women will not be entered on this study; pregnancy tests must be obtained in female patients who are post-menarchal; lactating females may not participate unless they have agreed not to breastfeed their infants; males or females of reproductive potential may not participate unless they have agreed to use an effective contraceptive method for the duration of the study treatment - All patients and/or their parents or legal guardians must sign a written informed consent - All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Trial Details

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

Trial ID:
NCT01231906

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase
Phase 3

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Lead Sponsor
Children's Oncology Group

The person who is responsible for the scientific and technical direction of the entire clinical study.

Principal Investigator
Patrick Leavey
Principal Investigator Affiliation Children's Oncology Group

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Agency Class
OtherNIH
Overall Status Active, not recruiting
Countries Australia, Canada, New Zealand, Puerto Rico, Saudi Arabia, United States

The disease, disorder, syndrome, illness, or injury that is being studied.

Conditions
Non-Metastatic Extraskeletal Ewing Sarcoma, Peripheral Primitive Neuroectodermal Tumor of Bone, Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
Additional Details

PRIMARY OBJECTIVES: l. Test the effect of the combination of vincristine (vincristine sulfate), cyclophosphamide, and topotecan (topotecan hydrochloride) (VTC) added to the standard 5-drug chemotherapy interval-compressed backbone on event-free and overall survival of children and young adults with Ewing sarcoma. SECONDARY OBJECTIVES:

  • I. To evaluate initial volumetric tumor size as a prognostic factor for event free survival (EFS) in patients with localized Ewing tumors.
  • II. To evaluate histologic response as a prognostic factor for EFS in patients with localized Ewing tumors.
  • III. To continue evaluation of biologic markers both as related to prognosis and as eventual therapeutic targets via encouraging concurrent enrollment on a Ewing sarcoma specimen-collection study.
  • IV. To evaluate imaging response by fludeoxyglucose F 18 (FDG)-positron emission tomography (PET) as a prognostic factor for EFS.
  • V. To evaluate the effects of the type of local therapy on EFS and overall survival.
  • VI. To evaluate the effect of local surgical margins in conjunction with histologic response on EFS in patients with localized Ewing tumors.
  • VII. To evaluate the effect of local therapy modality (surgery, radiotherapy, or a combination) as well as the type of surgical reconstruction on musculoskeletal complications.
OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM I: INDUCTION THERAPY: Patients receive vincristine sulfate intravenously (IV) on day 1 in weeks 1, 2, 5, 6, 9, and 10; doxorubicin hydrochloride IV on days 1 and 2 and cyclophosphamide IV over 30-60 minutes on day 1 in weeks 1, 5, and 9; and ifosfamide IV over 1 hour and etoposide IV over 1-2 hours on days 1-5 in weeks 3, 7, and 11. CONSOLIDATION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 7, 8, 9, 10, 13, 14, 17, 18, 21, and 22; doxorubicin hydrochloride IV on days 1 and 2 in weeks 1 and 9; cyclophosphamide IV over 30-60 minutes on day 1 in weeks 1, 7, 9, 13, 17, and 21; and ifosfamide IV over 1 hour and etoposide IV over 1-2 hours on days 1-5 in weeks 3, 5, 11, 15, and 19. ARM II: INDUCTION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 5, 6, 9, 10, 11 and 12; topotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1 and 9; cyclophosphamide IV over 15-60 minutes on days 1-5 in weeks 1 and 9, and on day 1 of weeks 5 and 11; ifosfamide and etoposide as in arm I; and doxorubicin hydrochloride IV on days 1 and 2 in weeks 5 and 11. CONSOLIDATION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 7-10, 13-16, 19, and 20; topotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1, 7, and 15; cyclophosphamide IV over 15-60 minutes on days 1-5 in weeks 1, 7, and 15, and on day 1 in weeks 9, 13, and 19; ifosfamide IV over 1 hour and etoposide IV over 1- 2 hours on days 1-5 in weeks 3, 5, 11, 17, and 21; and doxorubicin hydrochloride IV on days 1 and 2 in weeks 9,13, and 19. Patients with responsive or stable disease undergo may undergo surgery alone in week 13 if lesion can be complete resected with negative margins and with reasonable functional result. Patients with unresectable lesions or inadequate margins after surgery receive radiotherapy during weeks 1-7. Patients with bulky lesions in surgically difficult sites such as the spine, skull, and periacetabular pelvis, patients with a poor response to induction chemotherapy, or those patients in whom surgery would result in unacceptable functional results may undergo radiotherapy alone in weeks 1-7 of consolidation therapy, and surgery should be performed after completion of consolidation chemotherapy. Patients with microscopic residual disease after planned pre-operative radiotherapy receive additional radiotherapy. After completion of study therapy, patients are followed up every 3 months for 3 years and then every 6 months for 2 years.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Children's Hospital of Alabama, Birmingham, Alabama

Status

Address

Children's Hospital of Alabama

Birmingham, Alabama, 35233

Birmingham, Alabama

Status

Address

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

University of South Alabama, Mobile, Alabama

Status

Address

University of South Alabama

Mobile, Alabama, 36604

Providence Alaska Medical Center, Anchorage, Alaska

Status

Address

Providence Alaska Medical Center

Anchorage, Alaska, 99508

Phoenix Childrens Hospital, Phoenix, Arizona

Status

Address

Phoenix Childrens Hospital

Phoenix, Arizona, 85016

Tucson, Arizona

Status

Address

The University of Arizona Medical Center-University Campus

Tucson, Arizona, 85724

Arkansas Children's Hospital, Little Rock, Arkansas

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Address

Arkansas Children's Hospital

Little Rock, Arkansas, 72202-3591

Little Rock, Arkansas

Status

Address

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

Kaiser Permanente Downey Medical Center, Downey, California

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Address

Kaiser Permanente Downey Medical Center

Downey, California, 90242

City of Hope Comprehensive Cancer Center, Duarte, California

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Address

City of Hope Comprehensive Cancer Center

Duarte, California, 91010

Loma Linda University Medical Center, Loma Linda, California

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Address

Loma Linda University Medical Center

Loma Linda, California, 92354

Long Beach, California

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Address

Miller Children's and Women's Hospital Long Beach

Long Beach, California, 90806

Children's Hospital Los Angeles, Los Angeles, California

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Address

Children's Hospital Los Angeles

Los Angeles, California, 90027

Los Angeles County-USC Medical Center, Los Angeles, California

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Address

Los Angeles County-USC Medical Center

Los Angeles, California, 90033

USC / Norris Comprehensive Cancer Center, Los Angeles, California

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Address

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033

Cedars Sinai Medical Center, Los Angeles, California

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Address

Cedars Sinai Medical Center

Los Angeles, California, 90048

Mattel Children's Hospital UCLA, Los Angeles, California

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Address

Mattel Children's Hospital UCLA

Los Angeles, California, 90095

Los Angeles, California

Status

Address

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095

Valley Children's Hospital, Madera, California

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Address

Valley Children's Hospital

Madera, California, 93636

Oakland, California

Status

Address

Children's Hospital and Research Center at Oakland

Oakland, California, 94609-1809

Kaiser Permanente-Oakland, Oakland, California

Status

Address

Kaiser Permanente-Oakland

Oakland, California, 94611

Children's Hospital of Orange County, Orange, California

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Address

Children's Hospital of Orange County

Orange, California, 92868

Orange, California

Status

Address

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868

Palo Alto, California

Status

Address

Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304

Sutter Medical Center Sacramento, Sacramento, California

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Address

Sutter Medical Center Sacramento

Sacramento, California, 95816

Sacramento, California

Status

Address

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

Rady Children's Hospital - San Diego, San Diego, California

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Address

Rady Children's Hospital - San Diego

San Diego, California, 92123

UCSF Medical Center-Parnassus, San Francisco, California

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Address

UCSF Medical Center-Parnassus

San Francisco, California, 94143

UCSF Medical Center-Mission Bay, San Francisco, California

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Address

UCSF Medical Center-Mission Bay

San Francisco, California, 94158

Children's Hospital Colorado, Aurora, Colorado

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Address

Children's Hospital Colorado

Aurora, Colorado, 80045

Denver, Colorado

Status

Address

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

Denver, Colorado, 80218

Connecticut Children's Medical Center, Hartford, Connecticut

Status

Address

Connecticut Children's Medical Center

Hartford, Connecticut, 06106

Yale University, New Haven, Connecticut

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Address

Yale University

New Haven, Connecticut, 06520

Alfred I duPont Hospital for Children, Wilmington, Delaware

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Address

Alfred I duPont Hospital for Children

Wilmington, Delaware, 19803

MedStar Georgetown University Hospital, Washington, District of Columbia

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Address

MedStar Georgetown University Hospital

Washington, District of Columbia, 20007

Children's National Medical Center, Washington, District of Columbia

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Address

Children's National Medical Center

Washington, District of Columbia, 20010

Broward Health Medical Center, Fort Lauderdale, Florida

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Address

Broward Health Medical Center

Fort Lauderdale, Florida, 33316

Lee Memorial Health System, Fort Myers, Florida

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Address

Lee Memorial Health System

Fort Myers, Florida, 33901

Fort Myers, Florida

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Address

Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, 33908

Gainesville, Florida

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Address

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

Hollywood, Florida

Status

Address

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, Florida, 33021

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

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Address

Nemours Children's Clinic-Jacksonville

Jacksonville, Florida, 32207

Miami, Florida

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Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Miami Cancer Institute, Miami, Florida

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Address

Miami Cancer Institute

Miami, Florida, 33176

Florida Hospital Orlando, Orlando, Florida

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Address

Florida Hospital Orlando

Orlando, Florida, 32803

Arnold Palmer Hospital for Children, Orlando, Florida

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Address

Arnold Palmer Hospital for Children

Orlando, Florida, 32806

Nemours Children's Clinic - Orlando, Orlando, Florida

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Address

Nemours Children's Clinic - Orlando

Orlando, Florida, 32806

UF Cancer Center at Orlando Health, Orlando, Florida

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Address

UF Cancer Center at Orlando Health

Orlando, Florida, 32806

Nemours Children's Hospital, Orlando, Florida

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Address

Nemours Children's Hospital

Orlando, Florida, 32827

Nemours Children's Clinic - Pensacola, Pensacola, Florida

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Address

Nemours Children's Clinic - Pensacola

Pensacola, Florida, 32504

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

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Address

Johns Hopkins All Children's Hospital

Saint Petersburg, Florida, 33701

Tampa, Florida

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Address

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607

Saint Mary's Hospital, West Palm Beach, Florida

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Address

Saint Mary's Hospital

West Palm Beach, Florida, 33407

Atlanta, Georgia

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Address

Children's Healthcare of Atlanta - Egleston

Atlanta, Georgia, 30322

Augusta University Medical Center, Augusta, Georgia

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Augusta University Medical Center

Augusta, Georgia, 30912

Savannah, Georgia

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Address

Memorial Health University Medical Center

Savannah, Georgia, 31404

Straub Clinic and Hospital, Honolulu, Hawaii

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Address

Straub Clinic and Hospital

Honolulu, Hawaii, 96813

University of Hawaii Cancer Center, Honolulu, Hawaii

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University of Hawaii Cancer Center

Honolulu, Hawaii, 96813

Honolulu, Hawaii

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Address

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826

Tripler Army Medical Center, Honolulu, Hawaii

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Address

Tripler Army Medical Center

Honolulu, Hawaii, 96859

Boise, Idaho

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Address

Saint Luke's Mountain States Tumor Institute

Boise, Idaho, 83712

Lurie Children's Hospital-Chicago, Chicago, Illinois

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Address

Lurie Children's Hospital-Chicago

Chicago, Illinois, 60611

Northwestern University, Chicago, Illinois

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Address

Northwestern University

Chicago, Illinois, 60611

University of Illinois, Chicago, Illinois

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Address

University of Illinois

Chicago, Illinois, 60612

Chicago, Illinois

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Address

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

Loyola University Medical Center, Maywood, Illinois

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Address

Loyola University Medical Center

Maywood, Illinois, 60153

Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois

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Address

Advocate Children's Hospital-Oak Lawn

Oak Lawn, Illinois, 60453

Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois

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Address

Advocate Children's Hospital-Park Ridge

Park Ridge, Illinois, 60068

Advocate Lutheran General Hospital, Park Ridge, Illinois

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Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068

Saint Jude Midwest Affiliate, Peoria, Illinois

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Address

Saint Jude Midwest Affiliate

Peoria, Illinois, 61637

Saint John's Hospital, Springfield, Illinois

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Saint John's Hospital

Springfield, Illinois, 62702

Springfield, Illinois

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Southern Illinois University School of Medicine

Springfield, Illinois, 62702

Memorial Medical Center, Springfield, Illinois

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Memorial Medical Center

Springfield, Illinois, 62781

Indianapolis, Indiana

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Address

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202

Riley Hospital for Children, Indianapolis, Indiana

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Address

Riley Hospital for Children

Indianapolis, Indiana, 46202

Indianapolis, Indiana

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Address

Saint Vincent Hospital and Health Care Center

Indianapolis, Indiana, 46260

Blank Children's Hospital, Des Moines, Iowa

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Blank Children's Hospital

Des Moines, Iowa, 50309

Iowa City, Iowa

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Address

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242

Siouxland Regional Cancer Center, Sioux City, Iowa

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Siouxland Regional Cancer Center

Sioux City, Iowa, 51101

Mercy Medical Center-Sioux City, Sioux City, Iowa

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Address

Mercy Medical Center-Sioux City

Sioux City, Iowa, 51104

Saint Luke's Regional Medical Center, Sioux City, Iowa

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Saint Luke's Regional Medical Center

Sioux City, Iowa, 51104

Lexington, Kentucky

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Address

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

Norton Children's Hospital, Louisville, Kentucky

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Address

Norton Children's Hospital

Louisville, Kentucky, 40202

Tulane University Health Sciences Center, New Orleans, Louisiana

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Tulane University Health Sciences Center

New Orleans, Louisiana, 70112

Children's Hospital New Orleans, New Orleans, Louisiana

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Children's Hospital New Orleans

New Orleans, Louisiana, 70118

Ochsner Medical Center Jefferson, New Orleans, Louisiana

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Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121

Eastern Maine Medical Center, Bangor, Maine

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Eastern Maine Medical Center

Bangor, Maine, 04401

Maine Children's Cancer Program, Scarborough, Maine

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Maine Children's Cancer Program

Scarborough, Maine, 04074

Baltimore, Maryland

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University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

Sinai Hospital of Baltimore, Baltimore, Maryland

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Sinai Hospital of Baltimore

Baltimore, Maryland, 21215

Baltimore, Maryland

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Address

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

Bethesda, Maryland

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Address

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600

Boston, Massachusetts

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Address

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114

Dana-Farber Cancer Institute, Boston, Massachusetts

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Address

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215

Baystate Medical Center, Springfield, Massachusetts

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Baystate Medical Center

Springfield, Massachusetts, 01199

Worcester, Massachusetts

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Address

University of Massachusetts Medical School

Worcester, Massachusetts, 01655

C S Mott Children's Hospital, Ann Arbor, Michigan

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Address

C S Mott Children's Hospital

Ann Arbor, Michigan, 48109

Detroit, Michigan

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Address

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201

Ascension Saint John Hospital, Detroit, Michigan

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Address

Ascension Saint John Hospital

Detroit, Michigan, 48236

East Lansing, Michigan

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Address

Michigan State University Clinical Center

East Lansing, Michigan, 48824-7016

Hurley Medical Center, Flint, Michigan

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Address

Hurley Medical Center

Flint, Michigan, 48503

Grand Rapids, Michigan

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Address

Helen DeVos Children's Hospital at Spectrum Health

Grand Rapids, Michigan, 49503

Bronson Methodist Hospital, Kalamazoo, Michigan

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Address

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

Beaumont Children's Hospital-Royal Oak, Royal Oak, Michigan

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Address

Beaumont Children's Hospital-Royal Oak

Royal Oak, Michigan, 48073

Minneapolis, Minnesota

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Address

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, 55404

Minneapolis, Minnesota

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Address

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455

Mayo Clinic, Rochester, Minnesota

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Address

Mayo Clinic

Rochester, Minnesota, 55905

University of Mississippi Medical Center, Jackson, Mississippi

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Address

University of Mississippi Medical Center

Jackson, Mississippi, 39216

Columbia Regional, Columbia, Missouri

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Address

Columbia Regional

Columbia, Missouri, 65201

The Childrens Mercy Hospital, Kansas City, Missouri

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Address

The Childrens Mercy Hospital

Kansas City, Missouri, 64108

Washington University School of Medicine, Saint Louis, Missouri

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Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Mercy Hospital Saint Louis, Saint Louis, Missouri

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Address

Mercy Hospital Saint Louis

Saint Louis, Missouri, 63141

Omaha, Nebraska

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Address

Children's Hospital and Medical Center of Omaha

Omaha, Nebraska, 68114

University of Nebraska Medical Center, Omaha, Nebraska

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Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Las Vegas, Nevada

Status

Address

University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102

Nevada Cancer Research Foundation CCOP, Las Vegas, Nevada

Status

Address

Nevada Cancer Research Foundation CCOP

Las Vegas, Nevada, 89106

Sunrise Hospital and Medical Center, Las Vegas, Nevada

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Address

Sunrise Hospital and Medical Center

Las Vegas, Nevada, 89109

Las Vegas, Nevada

Status

Address

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135

Summerlin Hospital Medical Center, Las Vegas, Nevada

Status

Address

Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144

Saint Mary's Regional Medical Center, Reno, Nevada

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Address

Saint Mary's Regional Medical Center

Reno, Nevada, 89503

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Status

Address

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756

Hackensack University Medical Center, Hackensack, New Jersey

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Address

Hackensack University Medical Center

Hackensack, New Jersey, 07601

Saint Barnabas Medical Center, Livingston, New Jersey

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Address

Saint Barnabas Medical Center

Livingston, New Jersey, 07039

Morristown Medical Center, Morristown, New Jersey

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Address

Morristown Medical Center

Morristown, New Jersey, 07960

Saint Peter's University Hospital, New Brunswick, New Jersey

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Address

Saint Peter's University Hospital

New Brunswick, New Jersey, 08901

New Brunswick, New Jersey

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Address

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, New Jersey, 08903

Newark Beth Israel Medical Center, Newark, New Jersey

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Address

Newark Beth Israel Medical Center

Newark, New Jersey, 07112

Saint Joseph's Regional Medical Center, Paterson, New Jersey

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Address

Saint Joseph's Regional Medical Center

Paterson, New Jersey, 07503

Overlook Hospital, Summit, New Jersey

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Address

Overlook Hospital

Summit, New Jersey, 07902

University of New Mexico Cancer Center, Albuquerque, New Mexico

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Address

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102

Albany Medical Center, Albany, New York

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Address

Albany Medical Center

Albany, New York, 12208

Montefiore Medical Center - Moses Campus, Bronx, New York

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Address

Montefiore Medical Center - Moses Campus

Bronx, New York, 10467

Roswell Park Cancer Institute, Buffalo, New York

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Address

Roswell Park Cancer Institute

Buffalo, New York, 14263

New Hyde Park, New York

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Address

The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, New York, 11040

New York, New York

Status

Address

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016

Mount Sinai Hospital, New York, New York

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Address

Mount Sinai Hospital

New York, New York, 10029

New York, New York

Status

Address

Columbia University/Herbert Irving Cancer Center

New York, New York, 10032

University of Rochester, Rochester, New York

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Address

University of Rochester

Rochester, New York, 14642

Stony Brook University Medical Center, Stony Brook, New York

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Address

Stony Brook University Medical Center

Stony Brook, New York, 11794

Syracuse, New York

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Address

State University of New York Upstate Medical University

Syracuse, New York, 13210

New York Medical College, Valhalla, New York

Status

Address

New York Medical College

Valhalla, New York, 10595

Mission Hospital Inc-Memorial Campus, Asheville, North Carolina

Status

Address

Mission Hospital Inc-Memorial Campus

Asheville, North Carolina, 28801

Chapel Hill, North Carolina

Status

Address

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599

Charlotte, North Carolina

Status

Address

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203

Charlotte, North Carolina

Status

Address

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204

Duke University Medical Center, Durham, North Carolina

Status

Address

Duke University Medical Center

Durham, North Carolina, 27710

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Status

Address

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157

Sanford Broadway Medical Center, Fargo, North Dakota

Status

Address

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

Akron, Ohio

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Address

Children's Hospital Medical Center of Akron

Akron, Ohio, 44308

Cincinnati, Ohio

Status

Address

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Status

Address

Rainbow Babies and Childrens Hospital

Cleveland, Ohio, 44106

Cleveland Clinic Foundation, Cleveland, Ohio

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Address

Cleveland Clinic Foundation

Cleveland, Ohio, 44195

Nationwide Children's Hospital, Columbus, Ohio

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Address

Nationwide Children's Hospital

Columbus, Ohio, 43205

Dayton Children's Hospital, Dayton, Ohio

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Address

Dayton Children's Hospital

Dayton, Ohio, 45404

Toledo, Ohio

Status

Address

The Toledo Hospital/Toledo Children's Hospital

Toledo, Ohio, 43606

Mercy Children's Hospital, Toledo, Ohio

Status

Address

Mercy Children's Hospital

Toledo, Ohio, 43608

Oklahoma City, Oklahoma

Status

Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Tulsa, Oklahoma

Status

Address

Natalie Warren Bryant Cancer Center at Saint Francis

Tulsa, Oklahoma, 74136

Providence Saint Vincent Medical Center, Portland, Oregon

Status

Address

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

Legacy Emanuel Children's Hospital, Portland, Oregon

Status

Address

Legacy Emanuel Children's Hospital

Portland, Oregon, 97227

Portland, Oregon

Status

Address

Legacy Emanuel Hospital and Health Center

Portland, Oregon, 97227

Oregon Health and Science University, Portland, Oregon

Status

Address

Oregon Health and Science University

Portland, Oregon, 97239

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania

Status

Address

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017

Geisinger Medical Center, Danville, Pennsylvania

Status

Address

Geisinger Medical Center

Danville, Pennsylvania, 17822

Penn State Children's Hospital, Hershey, Pennsylvania

Status

Address

Penn State Children's Hospital

Hershey, Pennsylvania, 17033

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Status

Address

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Status

Address

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

Philadelphia, Pennsylvania

Status

Address

Saint Christopher's Hospital for Children

Philadelphia, Pennsylvania, 19134

Pittsburgh, Pennsylvania

Status

Address

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224

Rhode Island Hospital, Providence, Rhode Island

Status

Address

Rhode Island Hospital

Providence, Rhode Island, 02903

Medical University of South Carolina, Charleston, South Carolina

Status

Address

Medical University of South Carolina

Charleston, South Carolina, 29425

Palmetto Health Richland, Columbia, South Carolina

Status

Address

Palmetto Health Richland

Columbia, South Carolina, 29203

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

Status

Address

BI-LO Charities Children's Cancer Center

Greenville, South Carolina, 29605

Greenville Cancer Treatment Center, Greenville, South Carolina

Status

Address

Greenville Cancer Treatment Center

Greenville, South Carolina, 29605

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

Status

Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

T C Thompson Children's Hospital, Chattanooga, Tennessee

Status

Address

T C Thompson Children's Hospital

Chattanooga, Tennessee, 37403

East Tennessee Childrens Hospital, Knoxville, Tennessee

Status

Address

East Tennessee Childrens Hospital

Knoxville, Tennessee, 37916

St. Jude Children's Research Hospital, Memphis, Tennessee

Status

Address

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105

Nashville, Tennessee

Status

Address

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

Austin, Texas

Status

Address

Dell Children's Medical Center of Central Texas

Austin, Texas, 78723

Driscoll Children's Hospital, Corpus Christi, Texas

Status

Address

Driscoll Children's Hospital

Corpus Christi, Texas, 78411

Medical City Dallas Hospital, Dallas, Texas

Status

Address

Medical City Dallas Hospital

Dallas, Texas, 75230

Dallas, Texas

Status

Address

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

El Paso Children's Hospital, El Paso, Texas

Status

Address

El Paso Children's Hospital

El Paso, Texas, 79905

Brooke Army Medical Center, Fort Sam Houston, Texas

Status

Address

Brooke Army Medical Center

Fort Sam Houston, Texas, 78234

Cook Children's Medical Center, Fort Worth, Texas

Status

Address

Cook Children's Medical Center

Fort Worth, Texas, 76104

Houston, Texas

Status

Address

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030

M D Anderson Cancer Center, Houston, Texas

Status

Address

M D Anderson Cancer Center

Houston, Texas, 77030

Covenant Children's Hospital, Lubbock, Texas

Status

Address

Covenant Children's Hospital

Lubbock, Texas, 79410

Children's Hospital of San Antonio, San Antonio, Texas

Status

Address

Children's Hospital of San Antonio

San Antonio, Texas, 78207

San Antonio, Texas

Status

Address

Methodist Children's Hospital of South Texas

San Antonio, Texas, 78229

San Antonio, Texas

Status

Address

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229

Scott and White Memorial Hospital, Temple, Texas

Status

Address

Scott and White Memorial Hospital

Temple, Texas, 76508

Primary Children's Hospital, Salt Lake City, Utah

Status

Address

Primary Children's Hospital

Salt Lake City, Utah, 84113

Burlington, Vermont

Status

Address

University of Vermont College of Medicine

Burlington, Vermont, 05405

University of Virginia Cancer Center, Charlottesville, Virginia

Status

Address

University of Virginia Cancer Center

Charlottesville, Virginia, 22908

Inova Fairfax Hospital, Falls Church, Virginia

Status

Address

Inova Fairfax Hospital

Falls Church, Virginia, 22042

Norfolk, Virginia

Status

Address

Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507

Naval Medical Center - Portsmouth, Portsmouth, Virginia

Status

Address

Naval Medical Center - Portsmouth

Portsmouth, Virginia, 23708-2197

Richmond, Virginia

Status

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Carilion Clinic Children's Hospital, Roanoke, Virginia

Status

Address

Carilion Clinic Children's Hospital

Roanoke, Virginia, 24014

Seattle Children's Hospital, Seattle, Washington

Status

Address

Seattle Children's Hospital

Seattle, Washington, 98105

University of Washington Medical Center, Seattle, Washington

Status

Address

University of Washington Medical Center

Seattle, Washington, 98195

Spokane, Washington

Status

Address

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, Washington, 99204

Tacoma, Washington

Status

Address

Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, 98405

Madigan Army Medical Center, Tacoma, Washington

Status

Address

Madigan Army Medical Center

Tacoma, Washington, 98431

United Hospital Center, Bridgeport, West Virginia

Status

Address

United Hospital Center

Bridgeport, West Virginia, 26330

Charleston, West Virginia

Status

Address

West Virginia University Charleston Division

Charleston, West Virginia, 25304

West Virginia University Healthcare, Morgantown, West Virginia

Status

Address

West Virginia University Healthcare

Morgantown, West Virginia, 26506

Camden Clark Medical Center, Parkersburg, West Virginia

Status

Address

Camden Clark Medical Center

Parkersburg, West Virginia, 26101

Green Bay, Wisconsin

Status

Address

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301

Madison, Wisconsin

Status

Address

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792

Marshfield Clinic, Marshfield, Wisconsin

Status

Address

Marshfield Clinic

Marshfield, Wisconsin, 54449

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Status

Address

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53226

Milwaukee, Wisconsin

Status

Address

Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

International Sites

John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales, Australia

Status

Address

John Hunter Children's Hospital

Hunter Regional Mail Centre, New South Wales, 2310

Sydney Children's Hospital, Randwick, New South Wales, Australia

Status

Address

Sydney Children's Hospital

Randwick, New South Wales, 2031

The Children's Hospital at Westmead, Westmead, New South Wales, Australia

Status

Address

The Children's Hospital at Westmead

Westmead, New South Wales, 2145

Royal Brisbane and Women's Hospital, Herston, Queensland, Australia

Status

Address

Royal Brisbane and Women's Hospital

Herston, Queensland, 4029

Royal Children's Hospital-Brisbane, Herston, Queensland, Australia

Status

Address

Royal Children's Hospital-Brisbane

Herston, Queensland, 4029

Lady Cilento Children's Hospital, South Brisbane, Queensland, Australia

Status

Address

Lady Cilento Children's Hospital

South Brisbane, Queensland, 4101

Women's and Children's Hospital-Adelaide, North Adelaide, South Australia, Australia

Status

Address

Women's and Children's Hospital-Adelaide

North Adelaide, South Australia, 5006

Princess Margaret Hospital for Children, Perth, Western Australia, Australia

Status

Address

Princess Margaret Hospital for Children

Perth, Western Australia, 6008

Alberta Children's Hospital, Calgary, Alberta, Canada

Status

Address

Alberta Children's Hospital

Calgary, Alberta, T3B 6A8

University of Alberta Hospital, Edmonton, Alberta, Canada

Status

Address

University of Alberta Hospital

Edmonton, Alberta, T6G 2B7

British Columbia Children's Hospital, Vancouver, British Columbia, Canada

Status

Address

British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3V4

CancerCare Manitoba, Winnipeg, Manitoba, Canada

Status

Address

CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9

Janeway Child Health Centre, Saint John's, Newfoundland and Labrador, Canada

Status

Address

Janeway Child Health Centre

Saint John's, Newfoundland and Labrador, A1B 3V6

IWK Health Centre, Halifax, Nova Scotia, Canada

Status

Address

IWK Health Centre

Halifax, Nova Scotia, B3K 6R8

Hamilton, Ontario, Canada

Status

Address

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Ontario, L8N 3Z5

Kingston Health Sciences Centre, Kingston, Ontario, Canada

Status

Address

Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7

Children's Hospital, London, Ontario, Canada

Status

Address

Children's Hospital

London, Ontario, N6A 5W9

Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada

Status

Address

Children's Hospital of Eastern Ontario

Ottawa, Ontario, K1H 8L1

Hospital for Sick Children, Toronto, Ontario, Canada

Status

Address

Hospital for Sick Children

Toronto, Ontario, M5G 1X8

Montreal, Quebec, Canada

Status

Address

The Montreal Children's Hospital of the MUHC

Montreal, Quebec, H3H 1P3

Montreal, Quebec, Canada

Status

Address

Centre Hospitalier Universitaire Sainte-Justine

Montreal, Quebec, H3T 1C5

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Status

Address

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1

Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Status

Address

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4

Quebec, Canada

Status

Address

Centre Hospitalier Universitaire de Quebec

Quebec, , G1V 4G2

Starship Children's Hospital, Grafton, Auckland, New Zealand

Status

Address

Starship Children's Hospital

Grafton, Auckland, 1145

Christchurch Hospital, Christchurch, New Zealand

Status

Address

Christchurch Hospital

Christchurch, , 8011

San Jorge Children's Hospital, San Juan, Puerto Rico

Status

Address

San Jorge Children's Hospital

San Juan, , 00912

Riyadh, Saudi Arabia

Status

Address

King Faisal Specialist Hospital and Research Centre

Riyadh, , 11211

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