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Effect of Camel Milk on Insulin and Incretin Response

Study Purpose

To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Yes
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 20 Years - 70 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Normal glucose tolerance - BMI < 30 kg/m2

Exclusion Criteria:

- Type 1 diabetes mellitus - Type 2 diabetes mellitus - Impaired fasting glucose or impaired glucose tolerance - Lactose intolerance - Weight loss / gain ≥ 5 kg in the preceding two months - Use of estrogenic drugs or corticosteroids - Known hypertriglyceridemia requiring treatment - History of heart attack, angina or cardiovascular disorder - History of malignant tumor - Pregnant or lactating women - Hemoglobin < 12 for any reason - Recent surgery or major hemorrhage - History of bariatric or metabolic surgery

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03725969
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

N/A
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Imperial College London Diabetes Centre
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Dr Nader Lessan, MBBS MD FRCP
Principal Investigator Affiliation Imperial College London Diabetes Centre
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other
Overall Status Recruiting
Countries United Arab Emirates
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Insulin Sensitivity, Glucose Tolerance
Additional Details

Camel milk is used as a traditional remedy throughout the Middle East and Indian Subcontinent for conditions such as type 2 diabetes and dyslipidemia. It is currently unclear how such an effect could be mediated in vivo and studies are limited. We performed this study as a pilot experiment to assess the effects of camel milk on Insulin, Glucose, GLP-1, C-peptide and Lipid profile.

Arms & Interventions

Arms

Experimental: Healthy individuals (camel milk)

Experimental: Healthy individuals (cow milk)

Interventions

Dietary Supplement: - Camel milk

Camel Milk administered 10 minutes before a mixed meal of carbohydrate and protein; 2-week washout between interventions

Dietary Supplement: - Cow milk

Cow milk administered 10 minutes before a mixed meal of carbohydrate and protein;2-week washout between interventions

Contact a Trial Team

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International Sites

Imperial College London Diabetes Centre, Abu Dhabi, United Arab Emirates

Status

Recruiting

Address

Imperial College London Diabetes Centre

Abu Dhabi, , 48338

Site Contact

Nader Lessan, MBBS MD FRCP

nlessan@icldc.ae

+971 2 404 0800

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