Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
Searching Both is inclusive of interventional and observational studies.
|Eligible Ages||60 Years - 70 Years|
- - Aged between 60-70 years.
- - BMI between 25-35 kg/m2.
- - Fasting plasma glucose < 7.0 mmol/L.
- - Fasting serum total cholesterol < 8.0 mmol/L.
- - Fasting serum triacylglycerol < 4.5 mmol/L.
- - Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg.
- - Stable body weight (weight gain or loss < 3 kg in the past three months) - Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study.
- - No difficult venipuncture as evidenced during the screening visit.
- - Allergy or intolerance to nuts.
- - Left-handedness.
- - Current smoker, or smoking cessation < 12 months.
- - Diabetic patients.
- - Familial hypercholesterolemia.
- - Abuse of drugs.
- - More than 3 alcoholic consumptions per day.
- - Use of products or dietary supplements known to interfere with the main outcomes as judged by the principal investigators.
- - Use medication to treat blood pressure, lipid or glucose metabolism.
- - Use of an investigational product within another biomedical intervention trial within the previous 1-month.
- - Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis.
- - Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident.
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
|Maastricht University Medical Center|
The person who is responsible for the scientific and technical direction of the entire clinical study.
|Peter J Joris, PhD|
|Principal Investigator Affiliation||Maastricht University Medical Center|
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
The disease, disorder, syndrome, illness, or injury that is being studied.
|Brain Vascular Function, Cerebral Blood Flow|
No Intervention: Control
No mixed nuts
Dietary Supplement: - Mixed Nuts
Study volunteers will receive daily 60 g of mixed nuts (15 g walnut, 15 g cashew, 15 g hazelnut, 15 g pistachio) for 16 weeks.
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.