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Inclusion Criteria, at least one of the following:

• - Triaged as one of highest two triage categories (red or orange) according to the Manchester triage system; - Triaged as the third highest triage category (yellow) and arrival by EMS of Helicopter Emergency Medical Service (HEMS; - Shock.

• - Suspicion of sepsis (based on either physicians' suspicion, Sepsis-2 or Sepsis-3 criteria) - Acute kidney injury (AKI) - Anaphylactic reaction.

• - Syncope.

• - Intoxication.

• - Thrombosis.

• - Pulmonary embolism.

• - Bleeding while using anti-coagulant drugs.

• - Gastro-intestinal bleeding.

• - Electrolyte disturbance.

Exclusion Criteria:

• - Referred for organ transplantation as recipient.

• - Transfer from other hospital.

• - Accidental contact patient material (i.e. internal work-related accident) While data- and imaging will be collected from all these patients, biomaterials will only be collected from patients fulfilling the first criterion (i.e. triaged as one of highest two triage categories [red or orange] according to the Manchester triage system) and from patients with shock or a suspicion of sepsis.

Acutelines is a prospective biobank including patients with a broad spectrum of acute conditions. Its aim is to facilitate interdisciplinary research on the etiology and development of acute diseases with the aid of systematically collected biomaterials and medical data over various timepoints, both during the course of the patient's disease and after recovery. Clinical data, imaging data and biomaterial (i.e. blood, urine, feces, hair) are collected for patients presenting to the Emergency Department (ED) with a broad range of acute disease presentations. A deferred consent procedure (by proxy), is in place to allow collecting data and biomaterials prior to obtaining written consent. The digital infrastructure in place and the software used ensures automated capturing of all bed-side monitoring data (i.e. electrophysiological waveforms, vital parameters), and the secure importation of data from other sources, such as the electronic health records of the hospital, ambulance and general practitioner, municipal registration, health insurance companies and pharmacy. Follow up data are collected for all included patients during the first 72-hours of their hospitalization and 3-months, 1-year, 2-years and 5 years after their ED visit. Data and materials to be collected includes:

• - Demographic and health data (i.e. [experiences] health, quality of life, functional status) - Medical history (i.e. co-morbidity, intoxications, medication use) - Admission reason to emergency department.

• - Physical examination and vital parameters.

• - Clinical diagnostic data (i.e. [point-of-care] ultrasound, X-ray, CT-scan, laboratory results) - Electrophysiological waveforms (i.e. electrocardiogram [ECG], plethysmography) - Biomaterials.

- Treatment (i.e. medication use, non-pharmacological treatment, treatment decisions, length-of-stay in hospital, admission to intensive care unit [ICU])