Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma
Study Purpose
This phase II trial studies the effect of pembrolizumab alone compared to the usual approach (chemotherapy [cisplatin and carboplatin] plus radiation therapy) after surgery in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or patients with a second head and neck cancer that is not from metastasis (primary). Radiation therapy uses high energy radiation or protons to kill tumor cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Carboplatin is also in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving pembrolizumab alone after surgery may work better than the usual approach in shrinking recurrent or primary head and neck squamous cell carcinoma.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years - 79 Years |
| Gender | All |
Inclusion Criteria:
- - Patient must be between 18 and 79 years of age.
- - Patient must have locoregionally recurrent or second primary HNSCC (oral cavity, oropharynx, larynx, hypopharynx) in a previously radiated field.
- - Patient must have undergone surgery with gross total resection and must be randomized within 8 weeks of surgery.
- - Patients must have high risk disease defined as: - Positive margins and/or extra nodal extension (ENE) - Positive margins are defined as malignancy at or within 1 mm of the margin.
- - ENE may be either gross or microscopic.
- - Patient must have a PD-L1 Combined Positive Score (CPS) >= 1 in a Clinical Laboratory Improvement Act (CLIA) certified laboratory.
- - Patient must have had prior radiation to the area of recurrent or second primary tumor.
- - Patient must have completed prior radiation a minimum of 6 months prior to randomization.
- - Patient must not have any evidence of distant disease based on baseline imaging done within 28 days prior to randomization.
- - Patient must not have received anti-PD-1/PD-L1 therapy for recurrent disease.
- - Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
- - Patient must have the ability to understand and the willingness to sign a written informed consent document.
- - Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used.
- - Patient must not expect to conceive or father children by using by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse while on study treatment, and continue for 120 days after the last dose of study treatment.
- - Absolute neutrophil count (ANC) >= 1,500/mcL (obtained =< 28 days prior to protocol randomization) - Platelets >= 100,000/mcL (obtained =< 28 days prior to protocol randomization) - Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 28 days prior to protocol randomization) - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 3.0 x institutional ULN (obtained =< 28 days prior to protocol randomization) - Creatinine clearance > 30 ml/min using the Cockcroft-Gault formula (obtained =< 28 days prior to protocol randomization) - Patient must not have a current active infection that requires systemic treatment at time of randomization.
- - Patient must not have a history of non-infectious pneumonitis requiring steroids within 3 years prior to randomization.
- - Patient must not have a history of solid organ transplant or stem cell transplant.
- - Patient must not be on immunosuppressive medication within 7 days prior to randomization, EXCEPT for the following: a) intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b) systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; c) steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication) - Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional classification.
- - Patient must not have received a live vaccine within 30 days prior to the first dose of study drug.
- - Patient must not have severe hypersensitivity (>= grade 3) to pembrolizumab and/or any of its excipients.
- - Patient must not have an active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs).
- - Patient must not have a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study.
- - Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial as long as they have not been HIV-infected with a history of Kaposi sarcoma and/or multicentric Castleman disease.
- - Patient must not have a known history of hepatitis B (defined as hepatitis B surface antigen [HBsAg] reactive) or known active hepatitis C virus (defined as HCV ribonucleic acid [RNA] [qualitative] is detected) infection.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT04671667 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Dan P Zandberg |
| Principal Investigator Affiliation | ECOG-ACRIN Cancer Research Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH |
| Overall Status | Recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Oral Cavity Squamous Cell Carcinoma, Recurrent Oropharyngeal Squamous Cell Carcinoma |
PRIMARY OBJECTIVE:
- I. To evaluate overall survival (OS) of adjuvant pembrolizumab for 12 months compared to adjuvant reirradiation plus concurrent platinum chemotherapy in high risk head and neck squamous cell carcinoma (HNSCC) patients.
- I. To evaluate the following endpoints in both arms: disease free survival (DFS), locoregional control, rates of distant metastasis, toxicity.
- II. To evaluate whether high PD-L1 expression (defined as Combined Positive Score [CPS] >= 20) is predictive of increased efficacy in the experimental group compared to control.
Arms
Active Comparator: Arm B (cisplatin, carboplatin, IMRT, PBRT)
Patients receive cisplatin or carboplatin IV on day 1. Treatment repeats every 7 days for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo IMRT or PBRT QD for a total of 30 fractions in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI throughout the trial.
Experimental: Arm C (pembrolizumab)
Patients receive pembrolizumab IV over 30 minutes on day 1. Treatment repeats every 6 weeks for 9 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI throughout the trial.
Interventions
Drug: - Carboplatin
Given IV
Drug: - Cisplatin
Given IV
Procedure: - Computed Tomography
Undergo CT
Radiation: - Intensity-Modulated Radiation Therapy
Undergo IMRT
Procedure: - Magnetic Resonance Imaging
Undergo MRI
Biological: - Pembrolizumab
Given IV
Radiation: - Proton Beam Radiation Therapy
Undergo PBRT
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Suspended
Address
University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764, 35233
Status
Recruiting
Address
University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753, 72205
Status
Recruiting
Address
Kaiser Permanente-Anaheim
Anaheim 5323810, California 5332921, 92806
Status
Recruiting
Address
Kaiser Permanente-Bellflower
Bellflower 5327422, California 5332921, 90706
Status
Recruiting
Address
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine 5359777, California 5332921, 92612
Status
Recruiting
Address
UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921, 92093
Status
Recruiting
Address
Kaiser Permanente Los Angeles Medical Center
Los Angeles 5368361, California 5332921, 90027
Status
Recruiting
Address
Kaiser Permanente-Ontario
Ontario 5379439, California 5332921, 91761
Status
Recruiting
Address
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange 5379513, California 5332921, 92868
Status
Active, not recruiting
Address
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921, 95661
Status
Active, not recruiting
Address
Sutter Roseville Medical Center
Roseville 5388881, California 5332921, 95661
Status
Recruiting
Address
California Protons Cancer Therapy Center
San Diego 5391811, California 5332921, 92121
Status
Recruiting
Address
Smilow Cancer Center/Yale-New Haven Hospital
New Haven 4839366, Connecticut 4831725, 06510
Status
Recruiting
Address
Yale University
New Haven 4839366, Connecticut 4831725, 06520
Status
Recruiting
Address
Smilow Cancer Hospital Care Center-Trumbull
Trumbull 4844459, Connecticut 4831725, 06611
Status
Recruiting
Address
Smilow Cancer Hospital Care Center - Waterford
Waterford 8480031, Connecticut 4831725, 06385
Status
Active, not recruiting
Address
MedStar Washington Hospital Center
Washington D.C. 4140963, District of Columbia 4138106, 20010
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables 4151871, Florida 4155751, 33146
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach 4153071, Florida 4155751, 33442
Status
Active, not recruiting
Address
University of Florida Health Science Center - Gainesville
Gainesville 4156404, Florida 4155751, 32610
Status
Recruiting
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751, 33136
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation 4168782, Florida 4155751, 33324
Status
Suspended
Address
Moffitt Cancer Center-International Plaza
Tampa 4174757, Florida 4155751, 33607
Status
Recruiting
Address
Moffitt Cancer Center - McKinley Campus
Tampa 4174757, Florida 4155751, 33612
Status
Recruiting
Address
Moffitt Cancer Center
Tampa 4174757, Florida 4155751, 33612
Status
Recruiting
Address
Emory Proton Therapy Center
Atlanta 4180439, Georgia 4197000, 30308
Status
Recruiting
Address
Emory University Hospital Midtown
Atlanta 4180439, Georgia 4197000, 30308
Status
Suspended
Address
Emory University Hospital/Winship Cancer Institute
Atlanta 4180439, Georgia 4197000, 30322
Status
Suspended
Address
Memorial Health University Medical Center
Savannah 4221552, Georgia 4197000, 31404
Status
Recruiting
Address
Northwestern University
Chicago 4887398, Illinois 4896861, 60611
Status
Recruiting
Address
John H Stroger Jr Hospital of Cook County
Chicago 4887398, Illinois 4896861, 60612
Status
Recruiting
Address
University of Illinois
Chicago 4887398, Illinois 4896861, 60612
Status
Recruiting
Address
Carle at The Riverfront
Danville 4889426, Illinois 4896861, 61832
Status
Suspended
Address
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861, 62526
Status
Recruiting
Address
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861, 62526
Status
Recruiting
Address
Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861, 60115
Status
Recruiting
Address
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861, 62401
Status
Recruiting
Address
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861, 62401
Status
Recruiting
Address
Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861, 60134
Status
Active, not recruiting
Address
Northwestern Medicine Lake Forest Hospital
Lake Forest 4899012, Illinois 4896861, 60045
Status
Recruiting
Address
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861, 61938
Status
Recruiting
Address
Loyola University Medical Center
Maywood 4901514, Illinois 4896861, 60153
Status
Recruiting
Address
HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861, 62269
Status
Recruiting
Address
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861, 62702
Status
Recruiting
Address
Springfield Clinic
Springfield 4250542, Illinois 4896861, 62702
Status
Recruiting
Address
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861, 62781
Status
Recruiting
Address
Carle Cancer Center
Urbana 4914570, Illinois 4896861, 61801
Status
Suspended
Address
The Carle Foundation Hospital
Urbana 4914570, Illinois 4896861, 61801
Status
Recruiting
Address
Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861, 60555
Status
Active, not recruiting
Address
Reid Health
Richmond 4263681, Indiana 4921868, 47374
Status
Recruiting
Address
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182, 50023
Status
Recruiting
Address
Heartland Oncology and Hematology LLP
Council Bluffs 4852832, Iowa 4862182, 51503
Status
Recruiting
Address
Methodist Jennie Edmundson Hospital
Council Bluffs 4852832, Iowa 4862182, 51503
Status
Recruiting
Address
Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182, 50309
Status
Recruiting
Address
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182, 50309
Status
Recruiting
Address
Broadlawns Medical Center
Des Moines 4853828, Iowa 4862182, 50314
Status
Suspended
Address
Iowa Lutheran Hospital
Des Moines 4853828, Iowa 4862182, 50316
Status
Recruiting
Address
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182, 50263
Status
Suspended
Address
Methodist West Hospital
West Des Moines 4881346, Iowa 4862182, 50266-7700
Status
Active, not recruiting
Address
University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857, 66160
Status
Active, not recruiting
Address
University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857, 66210
Status
Active, not recruiting
Address
University of Kansas Hospital-Indian Creek Campus
Overland Park 4276873, Kansas 4273857, 66211
Status
Active, not recruiting
Address
University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857, 66205
Status
Recruiting
Address
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925, 40536
Status
Recruiting
Address
The James Graham Brown Cancer Center at University of Louisville
Louisville 4299276, Kentucky 6254925, 40202
Status
Recruiting
Address
UofL Health Medical Center Northeast
Louisville 4299276, Kentucky 6254925, 40245
Status
Suspended
Address
Maryland Proton Treatment Center
Baltimore 4347778, Maryland 4361885, 21201
Status
Recruiting
Address
University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885, 21201
Status
Recruiting
Address
Central Maryland Radiation Oncology in Howard County
Columbia 4352053, Maryland 4361885, 21044
Status
Recruiting
Address
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie 4356188, Maryland 4361885, 21061
Status
Recruiting
Address
Tufts Medical Center
Boston 4930956, Massachusetts 6254926, 02111
Status
Suspended
Address
University of Michigan Comprehensive Cancer Center
Ann Arbor 4984247, Michigan 5001836, 48109
Status
Active, not recruiting
Address
Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836, 48201
Status
Active, not recruiting
Address
Weisberg Cancer Treatment Center
Farmington Hills 4992523, Michigan 5001836, 48334
Status
Recruiting
Address
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779, 56601
Status
Recruiting
Address
University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296, 39216
Status
Suspended
Address
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678, 63703
Status
Active, not recruiting
Address
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters 4407237, Missouri 4398678, 63376
Status
Active, not recruiting
Address
Siteman Cancer Center at West County Hospital
Creve Coeur 4382837, Missouri 4398678, 63141
Status
Active, not recruiting
Address
University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678, 64154
Status
Active, not recruiting
Address
University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678, 64064
Status
Active, not recruiting
Address
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City 4400860, Missouri 4398678, 64116
Status
Suspended
Address
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678, 65804
Status
Active, not recruiting
Address
Washington University School of Medicine
St Louis 4407066, Missouri 4398678, 63110
Status
Recruiting
Address
Mercy Hospital South
St Louis 4407066, Missouri 4398678, 63128
Status
Active, not recruiting
Address
Siteman Cancer Center-South County
St Louis 4407066, Missouri 4398678, 63129
Status
Active, not recruiting
Address
Siteman Cancer Center at Christian Hospital
St Louis 4407066, Missouri 4398678, 63136
Status
Recruiting
Address
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678, 63141
Status
Recruiting
Address
Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009, 59405
Status
Recruiting
Address
Logan Health Medical Center
Kalispell 5660340, Montana 5667009, 59901
Status
Recruiting
Address
Community Medical Center
Missoula 5666639, Montana 5667009, 59804
Status
Recruiting
Address
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha 5074472, Nebraska 5073708, 68114
Status
Recruiting
Address
Nebraska Methodist Hospital
Omaha 5074472, Nebraska 5073708, 68114
Status
Suspended
Address
Oncology Associates PC
Omaha 5074472, Nebraska 5073708, 68114
Status
Recruiting
Address
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136, 87106
Status
Recruiting
Address
Mount Sinai Union Square
New York 5128581, New York 5128638, 10003
Status
Recruiting
Address
Mount Sinai Chelsea
New York 5128581, New York 5128638, 10011
Status
Recruiting
Address
Mount Sinai Hospital
New York 5128581, New York 5128638, 10029
Status
Recruiting
Address
University of Rochester
Rochester 5134086, New York 5128638, 14642
Status
Recruiting
Address
Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638, 11794
Status
Recruiting
Address
Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638, 10461
Status
Recruiting
Address
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638, 10467
Status
Recruiting
Address
Wilmot Cancer Institute at Webster
Webster 5143495, New York 5128638, 14580
Status
Suspended
Address
Randolph Hospital
Asheboro 4453035, North Carolina 4482348, 27203
Status
Recruiting
Address
Cone Health Cancer Center
Greensboro 4469146, North Carolina 4482348, 27403
Status
Recruiting
Address
Annie Penn Memorial Hospital
Reidsville 4487682, North Carolina 4482348, 27320
Status
Recruiting
Address
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763, 58501
Status
Recruiting
Address
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763, 58122
Status
Active, not recruiting
Address
Indu and Raj Soin Medical Center
Beavercreek 4506008, Ohio 5165418, 45431
Status
Active, not recruiting
Address
Dayton Physicians LLC-Miami Valley South
Centerville 4508204, Ohio 5165418, 45459
Status
Recruiting
Address
Miami Valley Hospital South
Centerville 4508204, Ohio 5165418, 45459
Status
Recruiting
Address
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418, 44195
Status
Recruiting
Address
Premier Blood and Cancer Center
Dayton 4509884, Ohio 5165418, 45409
Status
Active, not recruiting
Address
Dayton Physician LLC - Englewood
Dayton 4509884, Ohio 5165418, 45415
Status
Recruiting
Address
Miami Valley Hospital North
Dayton 4509884, Ohio 5165418, 45415
Status
Recruiting
Address
Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418, 45005-1066
Status
Active, not recruiting
Address
Dayton Physicians LLC-Atrium
Franklin 4512203, Ohio 5165418, 45005
Status
Recruiting
Address
Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418, 45331
Status
Active, not recruiting
Address
Greater Dayton Cancer Center
Kettering 4515843, Ohio 5165418, 45409
Status
Active, not recruiting
Address
Kettering Medical Center
Kettering 4515843, Ohio 5165418, 45429
Status
Recruiting
Address
Upper Valley Medical Center
Troy 5174358, Ohio 5165418, 45373
Status
Recruiting
Address
Cancer Centers of Southwest Oklahoma Research
Lawton 4540737, Oklahoma 4544379, 73505
Status
Recruiting
Address
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379, 73104
Status
Suspended
Address
Clackamas Radiation Oncology Center
Clackamas 5719308, Oregon 5744337, 97015
Status
Suspended
Address
Providence Cancer Institute Clackamas Clinic
Clackamas 5719308, Oregon 5744337, 97015
Status
Recruiting
Address
Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337, 97132
Status
Recruiting
Address
Providence Portland Medical Center
Portland 5746545, Oregon 5744337, 97213
Status
Recruiting
Address
Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337, 97225
Status
Recruiting
Address
UPMC Altoona
Altoona 5178195, Pennsylvania 6254927, 16601
Status
Recruiting
Address
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927, 17822
Status
Recruiting
Address
UPMC Hillman Cancer Center Erie
Erie 5188843, Pennsylvania 6254927, 16505
Status
Recruiting
Address
UPMC Cancer Center at UPMC Horizon
Farrell 5189377, Pennsylvania 6254927, 16121
Status
Recruiting
Address
Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927, 17837
Status
Recruiting
Address
UPMC Hillman Cancer Center - New Castle
New Castle 5203127, Pennsylvania 6254927, 16105
Status
Recruiting
Address
Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927, 19107
Status
Recruiting
Address
Fox Chase Cancer Center
Philadelphia 4560349, Pennsylvania 6254927, 19111
Status
Recruiting
Address
Jefferson Torresdale Hospital
Philadelphia 4560349, Pennsylvania 6254927, 19114
Status
Active, not recruiting
Address
Temple University Hospital
Philadelphia 4560349, Pennsylvania 6254927, 19140
Status
Recruiting
Address
UPMC-Saint Margaret
Pittsburgh 5206379, Pennsylvania 6254927, 15215
Status
Recruiting
Address
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927, 15232
Status
Active, not recruiting
Address
UPMC-Shadyside Hospital
Pittsburgh 5206379, Pennsylvania 6254927, 15232
Status
Recruiting
Address
UPMC-Passavant Hospital
Pittsburgh 5206379, Pennsylvania 6254927, 15237
Status
Recruiting
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927, 18711
Status
Recruiting
Address
UPMC Memorial
York 4562407, Pennsylvania 6254927, 17408
Status
Recruiting
Address
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040, 29425
Status
Recruiting
Address
Avera Cancer Institute
Sioux Falls 5231851, South Dakota 5769223, 57105
Status
Recruiting
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223, 57117-5134
Status
Recruiting
Address
Avera Cancer Institute at Yankton
Yankton 5233053, South Dakota 5769223, 57078
Status
Recruiting
Address
Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168, 37232
Status
Active, not recruiting
Address
Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030, 84112
Status
Recruiting
Address
VCU Massey Cancer Center at Stony Point
Richmond 4781708, Virginia 6254928, 23235
Status
Recruiting
Address
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928, 23298
Status
Recruiting
Address
ThedaCare Regional Cancer Center
Appleton 5244080, Wisconsin 5279468, 54911
Status
Suspended
Address
HSHS Sacred Heart Hospital
Eau Claire 5251436, Wisconsin 5279468, 54701
Status
Recruiting
Address
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468, 54301
Status
Recruiting
Address
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468, 54303
Status
Recruiting
Address
Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468, 53051
Status
Recruiting
Address
Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468, 53226
Status
Recruiting
Address
Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468, 53154
Status
Recruiting
Address
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468, 54235-1495
Status
Recruiting
Address
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468, 53095
