Allergenicity Assessment of Green Marine Macroalga Ulva sp.

Study Purpose

To determine the allergenic potential in humans, we will conduct a three-stage clinical trial. In the first group, 20 healthy volunteers will be involved. All volunteers will be examined by an allergy specialist before enrolment to the study. After receiving informed consent, all volunteers will undergo an allergy skin test to the study seaweed proteins as well as to common allergens. Participants with a skin test showing sensitization will be excluded. Volunteers will be fed by 5 gram of the study seaweed 2 times a week, under supervision, for 6 weeks. After 6 weeks of feeding, skin tests will be repeated. All participants, will undergo an open oral food challenge after one month of avoidance of the study seaweed protein. Uneventful food challenge will rule out food allergy in a specific volunteer. Second, the extension clinical phase will be conducted with 100 healthy volunteers. The inclusion, exclusion and study design will be similar to the pilot study. The third phase will be conducted in a group of high-risk patients aimed to find the frequency of allergy to the study seaweed in high risk patients. Study population: 20 volunteers with high risk to seaweed food allergy. Inclusion criteria: Adults (>18 years old, males and females) with at least one of the following: Active atopic dermatitis or fish or sea food allergy. Study design will be similar to the pilot study.

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	Yes
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Observational [Patient Registry]
Eligible Ages	18 Years and Over
Gender	All

More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Adults (>18) - Males and females (10 males and 10 females) with no history of food allergy or atopy.

Exclusion Criteria:

- Any history of food allergy, women pregnant or lactating, any history of atopy (moderate/severe atopic dermatitis, allergic rhinitis, asthma), any chronic diseases, any chronic medication use (except CP).

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT06452381
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	Meir Medical Center
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	N/A
Principal Investigator Affiliation	N/A
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Other
Overall Status	Active, not recruiting
Countries	Israel
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	Food Allergy

Additional Details

To determine the allergenic potential in humans, we will conduct a three-stage clinical trial. The length of each phase will be 3 months. Serum will be sampled from all the participants before and at the end of each phase. In the first group, 20 volunteers will be involved. Inclusion criteria: Adults (>18); Males and females (10 males and 10 females) with no history of food allergy or atopy. Exclusion criteria: any history of food allergy, women pregnant or lactating, any history of atopy (moderate/severe atopic dermatitis, allergic rhinitis, asthma), any chronic diseases, any chronic medication use (except CP). Study design: All volunteers will be examined by an allergy specialist before enrolment to the study to rule out any of the exclusion criteria. Volunteers with any of the exclusion criteria will be excluded from participation in this part of the study. After receiving informed consent, all volunteers will undergo an allergy skin test to the study seaweed proteins as well as to fish, sea foods , peanut, sesame, milk, soy, house dust mite and common Israeli pollens. Participants with a skin test showing sensitization by skin tests will be excluded from this part of the study. All volunteers passing the above stages will be enrolled. Volunteers will be fed by 5 gram of the study seaweed 2 times a week, under supervision, for 6 weeks. After 6 weeks of feeding, skin tests will be repeated. All participants, disregarding the results of the skin test, will undergo an open oral food challenge after one month of avoidance of the study seaweed protein. The open oral food challenge will include ingestion of 5 gram of the study seaweed protein and 2 hours of observation. An allergic reaction to the food challenge will be determined by the allergy specialist conducting the food challenge by predefined clinical signs and symptoms. If needed, first aid treatment will be provided by the allergy specialist. Uneventful food challenge will rule out food allergy in a specific volunteer. Expected results: we assume that the study seaweed is not more allergenic than other common foods. Thus, we expect that no more than one volunteer will have a reaction to the food challenge. Second, the extension clinical phase will be conducted with 100 healthy volunteers. The sample size was based on the prevalence of IgE mediated food allergy (of all kinds) in the general population and engineering constraints for extraction process scale up. Finding at least one person with the allergy should be around 63% confidence under the prevalence of 1%, and 95% confidence under a prevalence of 3% and a sample size of 100. The inclusion, exclusion and study design will be similar to the pilot study. Blood test will be drawn from patients that will be found to be allergic to the seaweed in order to try to define specific allergenic epitopes of the seaweed. Expected outcomes: allergy to the study seaweed will be found in less than 5% of healthy volunteers. The third phase will be conducted in a group of high-risk patients aimed to find the frequency of allergy to the study seaweed in high risk patients. Study population: 20 volunteers with high risk to seaweed food allergy. Inclusion criteria: Adults (>18 years old, males and females) with at least one of the following: Active atopic dermatitis or fish or sea food allergy. Study design will be similar to the pilot study. Blood tests will be drawn from patients that will be found to be allergic to the seaweed in order to try and define specific allergenic epitopes of the seaweed. We expect that allergy to the study seaweed protein will be found in less than 10% of high-risk volunteers.

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International Sites

Meir Medical Center, Kfar Saba, Israel

Status

Address

Meir Medical Center

Kfar Saba, , 428164

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