Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals

Study Purpose

The study aims to assess the effects of daily consumption of nutrients-fortified eggs on eczema condition in Singapore individuals with eczema. The investigators hypothesize that egg consumption will improve eczema condition and nutrients fortified egg consumption will improve further improvements when compared to standard egg consumption in individuals with eczema

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	Yes
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Interventional
Eligible Ages	21 Years - 59 Years
Gender	All

More Inclusion & Exclusion Criteria

Inclusion Criteria:

1. English-literate and able to give informed consent in English. 2. Male and female participants, aged between 21 and 59 inclusive. 3. Healthy individuals with no underlying condition or on regular medication. 4. BMI between 18.5-25 kg/m2. 5. Mild to moderate severity of eczema, which will also be determined using our questionnaires during the screening visit.

Exclusion Criteria:

1. Significant change in body weight (3 kg or more) in the past 3 months. 2. Significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week. 3. Known food allergy to eggs. 4. Taking dietary supplements which may impact the study results. 5. Having gastrointestinal disorders not suitable for the study. 6. Current smokers. 7. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine, 340ml of beer/cider, or 45ml of distilled spirit. 8. Taking lipid-lowering and blood pressure-controlling medications for less than 3 years. 9. Pregnant or lactating women, or planning to conceive in the next 6 months. 10. Unwilling to stop the medication of eczema during the study, either topical creams or oral medications. 11. Hierarchical link (professional and familial ties) with the research team members. 12. Participating in another clinical study. 13. Having blindness in one eye or more, eye diseases, retinal/lens/optical nerve surgery, or other eye conditions that may impact the study results. 14. Low-quality macular pigment optical density results were determined during the screening visit.

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT06454942
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.	N/A
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	National University of Singapore
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	Jung Eun Kim, PhD, RD
Principal Investigator Affiliation	National University of Singapore
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Other
Overall Status	Recruiting
Countries	Singapore
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	Atopic Dermatitis Eczema, Aging, Diet Modification

Additional Details

This is a double-blind, randomized, parallel study and all subjects will complete a 12-week study period. Subjects will be tasked to consume nutrients-fortified eggs and regular eggs daily for 12 weeks. After which, subjects are assessed for changes in carotenoid status, antioxidant and anti-inflammatory biomarkers, skin and eye health measurements, and other biomarkers of health.

Arms & Interventions

Arms

Experimental: Regular egg with habitual diet

Each subject will be provide one-on-one dietary counselling and written instructions for each subject will be provided by a research dietitian and trained research staff.Subjects will also be provided with 2 regular egg/day for 12 weeks.

Experimental: Nutrient-fortified egg with habitual diet

Interventions

Dietary Supplement: - Nutrient-fortified egg

Consumption of nutrient-fortified eggs with habitual diet

Dietary Supplement: - Regular egg with habitual diet

Consumption of regular egg with habitual diet

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

International Sites

Singapore, Singapore

Status

Recruiting

Address

Department of Food Science and Techonology, Block S13

Singapore, , 117550

Site Contact

Si Jia Tan

[email protected]

+65 6516 1656

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